Publications
For peer-review
Vadakkan K.I
(2017) A potential mechanism for the first-person inner sensation of
memory provides evidence for a relationship between learning and LTP
induction
Vadakkan K.I (2016) A first-principle for the nervous system functions. Article
Peer-reviewed
Vadakkan K.I (2016) Substantive nature of sleep in updating the temporal conditions necessary for inducing units of internal sensations. Sleep Science (Sleep is part of the substance of the nervous system. The system becomes operational only in the presence of sleep. Without sleep, the system cannot continue to function. In fact, without sleep, there is no system! This finding provides evidence for the hypothesised mechanism). Article
Vadakkan K.I (2016) Neurodegenerative disorders share common features of "loss of function" states of a proposed mechanism of nervous system functions. Biomedicine and Pharmacotherapy. (This work was carried out with a simple idea that just by sitting in a workshop and watching how defects of the cars are being repaired for a period time, we will get some idea how a car works normally. In the case of the nervous system, the observations in various neurodegenerative disorders match with the defects in the hypothesized mechanism). Article
Vadakkan K.I (2016) Rapid chain-generation of inter-postsynaptic functional LINKs can trigger seizure generation: Evidence for potential interconnections from pathology to behavior. Epilepsy and Behavior (This work provides an opportunity to triangulate large number of findings from different levels to examine a possible normal operational mechanism of the system) Article
Vadakkan K.I (2016) The functional role of
all postsynaptic potentials examined from a first-person frame of
reference. Reviews in the Neurosciences (
Vadakkan K.I (2015) A framework for the first-person internal sensation of visual perception in mammals and a comparable circuitry for olfactory perception in Drosophila. SpringerPlus (This work explains and interconnects several third person findings in visual perception and optics. Presence of a comparable circuitry in a different sensory system in a remote animal species provides support for the presented mechanism) Article
Vadakkan K.I (2015; Revised 2017) The
necessity for the observer to examine the system from a first-person
frame of reference to trace the path of generation of inner sensations.
F1000 Research
Article
Vadakkan
K.I (2015) A pressure-reversible cellular mechanism of general
anesthetics capable of altering a possible mechanism for consciousness.
SpringerPlus (This paper explains how
anesthetic requirement is reduced in the presence of dopamine that causes
enlargement of dendritic spines)
Article
Vadakkan K.I (2014) An electronic circuit model of the
inter-postsynaptic functional LINK designed to study the formation of
internal sensations in the nervous system.
Advances in Artificial Neural Systems.
Article
Vadakkan K.I (2013) A supplementary circuit rule-set for the neuronal
wiring. Frontiers in Human Neuroscience (A
testable brain activity map is explained in this paper).
Article
Vadakkan K.I (2012) A structure-function
mechanism for schizophrenia.
Frontiers in Psychiatry
(This work has identified rapidly reversible, yet stabilizable membrane
hemi-fusion as a possible mechanism for inter-postsynaptic functional LINKs).
Article
Vadakkan K.I (2012) The nature of "internal
sensations" of higher brain functions may be derived from the design
rules for artificial machines that can produce them. Journal
of Biological Engineering (This website is dedicated to the
character LISNE in this paper).
Article
Vadakkan K.I (2011) Processing semblances
induced through inter-postsynaptic functional LINKs, presumed biological
parallels of K-lines proposed for building artificial intelligence.
Frontiers in Neuroengineering.
Article
Vadakkan K.I (2011) A possible mechanism of
transfer of memories from the hippocampus to the cortex.
Medical Hypotheses.
Article
Vadakkan K.I (2010) Framework of
consciousness from semblance of activity at functionally LINKed
postsynaptic membranes.
Frontiers in Psychology
(Consciousness Research).
Article
Video presentations
1. A testable hypothesis of brain functions
Video
4. List
of third person findings and the derivation of the solution for the
nervous system
Video
5.
Constraints to work with
Video
6.
Induction of units of inner sensation Video
8. A potential mechanism for neurodegeneration Video
9. LTP: An explanation by semblance hypothesis Video
10. A framework for consciousness Video
11. A potential mechanism of anaesthetic agents Video
Books
Vadakkan K.I (2010) Semblance hypothesis of
memory. 3rd Edition ISBN: 978-1-4502-5620-9
Vadakkan K.I (2008) Semblance hypothesis of
memory. 2nd Edition ISBN: 978-1-4401-0754-2
Vadakkan K.I (2007) Semblance of activity at
the shared post-synapses and extracellular matrices - A structure
function hypothesis of memory. ISBN:978-0-5954-7002-0
Download
Presentations
Center for Neuroscience, Indian Institute of
Science, Bangalore. August 11th, 2017. Title: Why did Camillo Golgi disagree with
the Neuron doctrine?
Society for Neuroscience annual meeting
- Satellite event. October 17th, 2015. Title: Examining nervous system
functions from a first-person frame of reference using the semblance
hypothesis.
Society for Neuroscience annual meeting -
Satellite event.
November 17th, 2014. Title: Exploring the mind using the
semblance hypothesis.
Society for Neuroscience annual meeting -
Satellite event.
November 2013. Title: Internal Sensations,
Artificial intelligence and the semblance hypothesis.
Florida State University, Department of
Scientific Computing seminar. February, 2013. Title: Transferable units from natural
Intelligence: Proof requires AI development.
University of New Mexico, Department of
Computer Science colloquium. January 2013. Title: Natural intelligence
to artificial intelligence - A new route that can be taken. (video). I apologize to the molecular biologists for my comment that discoveries
were over in molecular biology. It is the lack of matching advancement in neuroscience that made me to
say that).
Society for Neuroscience annual meeting -
Satellite event. October 15th, 2012. Title: Reducing internal sensation of
retrieved memories using the semblance hypothesis.
Society for Neuroscience annual meeting -
Satellite event. November 13th, 2011. Topic: Semblance hypothesis of memory:
Computational modelling and development of artificial circuits.
Society for Neuroscience annual meeting -
Satellite event. November 14th, 2010. Topic: Semblance hypothesis of memory - Transfer
of memories from the hippocampus to the cortex.
Society for Neuroscience annual meeting -
Satellite event. October 18th, 2009. Topic: Semblance hypothesis of memory - A
presentation.
Abstracts
Vadakkan K.I (2013) A structural unit of
brain network that can operate in unison with synaptic connections and
can impart needed functions. Cell symposium on the topic "Networked
Brain" at the Society for Neuroscience meeting November 8
Poster
Vadakkan K.I (2012) Induced p-semblances as
a possible mechanism for the internal sensation of pain. Society for
Neuroscience Annual meeting, Oct.16. Abstract
674.25/HH10
Vadakkan K.I (2012) Perception as the
integral of semblances formed by re-activation of existing previously
formed functional LINKs between the postsynapses. Cognitive Neuroscience
Society meeting, April 3rd, Abstract H90
Vadakkan K.I (2011) Semblions induced
through inter-postsynaptic functional LINKs, biological parallels of
K-lines, as basic units of internal sensations. Society for Neuroscience
conference, Abstract 722.16/XX68
Vadakkan K.I (2010) Framework of
consciousness from the semblance hypothesis of memory. Toward a science
of consciousness Conference, Tucson, University of Arizona. Abstract No:
P-8
Vadakkan K.I (2009) Delusions, cognitive
impairment and the therapeutic effect of dopamine receptor antagonists
in schizophrenia - An explanation through the semblance hypothesis of
memory. Society for Neuroscience conference, Poster Abstract: 644.3/U18
Vadakkan K.I (2008) Oxidation-state
dependent interconnections between dendritic spines provide early
evidence in support of semblance hypothesis of memory. Society for
Neuroscience conference, Abstract: 239.19/E16
Vadakkan K.I (2008) Examination of the
premises of semblance hypothesis that can explain retrieval-efficient
mechanism of memory at appropriate time-scales. Second Canadian
Association for Neuroscience annual meeting, Montreal.
Abstract A-G 118