Semblance Hypothesis

Publications

 

For peer-review

 

Vadakkan K.I (2017) A potential mechanism for the first-person inner sensation of memory provides evidence for a relationship between learning and LTP induction. Article

 

Vadakkan K.I (2016) A first-principle for the nervous system functions. Article

 

Peer-reviewed

 

Vadakkan K.I (2016) Substantive nature of sleep in updating the temporal conditions necessary for inducing units of internal sensations. Sleep Science (Sleep is part of the substance of the nervous system. The system becomes operational only in the presence of sleep. Without sleep, the system cannot continue to function. In fact, without sleep, there is no system! This finding provides evidence for the hypothesised mechanism). Article

Vadakkan K.I (2016) Neurodegenerative disorders share common features of "loss of function" states of a proposed mechanism of nervous system functions. Biomedicine and Pharmacotherapy. (This work was carried out with a simple idea that just by sitting in a workshop and watching how defects of the cars are being repaired for a period time, we will get some idea how a car works normally. In the case of the nervous system, the observations in various neurodegenerative disorders match with the defects in the hypothesized mechanism). Article

Vadakkan K.I (2016) Rapid chain-generation of inter-postsynaptic functional LINKs can trigger seizure generation: Evidence for potential interconnections from pathology to behavior. Epilepsy and Behavior (This work provides an opportunity to triangulate large number of findings from different levels to examine a possible normal operational mechanism of the system) Article

Vadakkan K.I (2016) The functional role of all postsynaptic potentials examined from a first-person frame of reference. Reviews in the Neurosciences (Explained how a neuronal soma is flanked by a large number of internal sensory processing units and their relationship with neuronal firing) Article

Vadakkan K.I (2015) A framework for the first-person internal sensation of visual perception in mammals and a comparable circuitry for olfactory perception in Drosophila. SpringerPlus (This work explains and interconnects several third person findings in visual perception and optics. Presence of a comparable circuitry in a different sensory system in a remote animal species provides support for the presented mechanism) Article

Vadakkan K.I (2015; Revised 2017) The necessity for the observer to examine the system from a first-person frame of reference to trace the path of generation of inner sensations. F1000 Research  Article

Vadakkan K.I (2015) A pressure-reversible cellular mechanism of general anesthetics capable of altering a possible mechanism for consciousness. SpringerPlus (This paper explains how anesthetic requirement is reduced in the presence of dopamine that causes enlargement of dendritic spines) Article


Vadakkan K.I (2014) An electronic circuit model of the inter-postsynaptic functional LINK designed to study the formation of internal sensations in the nervous system.
Advances in Artificial Neural Systems. Article

Vadakkan K.I (2013) A supplementary circuit rule-set for the neuronal wiring. Frontiers in Human Neuroscience (A testable brain activity map is explained in this paper).
Article

Vadakkan K.I (2012) A structure-function mechanism for schizophrenia. Frontiers in Psychiatry (This work has identified rapidly reversible, yet stabilizable membrane hemi-fusion as a possible mechanism for inter-postsynaptic functional LINKs). Article

Vadakkan K.I (2012) The nature of "internal sensations" of higher brain functions may be derived from the design rules for artificial machines that can produce them. Journal of Biological Engineering (This website is dedicated to the character LISNE in this paper). Article

Vadakkan K.I (2011) Processing semblances induced through inter-postsynaptic functional LINKs, presumed biological parallels of K-lines proposed for building artificial intelligence. Frontiers in Neuroengineering. Article

Vadakkan K.I (2011) A possible mechanism of transfer of memories from the hippocampus to the cortex. Medical Hypotheses. Article

Vadakkan K.I (2010) Framework of consciousness from semblance of activity at functionally LINKed postsynaptic membranes. Frontiers in Psychology (Consciousness Research). Article

Video presentations

1. A testable hypothesis of brain functions     Video

2. How to study inner sensations? Examples from mathematics     Video

3. Neurons and Synapses    Video

4. List of third person findings and the derivation of the solution for the nervous syste         Video    

5. Constraints to work with     Video

6. Induction of units of inner sensation      Video

7. Why do we need to sleep?      Vidieo

8. A potential mechanism for neurodegeneration     Video

9. LTP: An explanation by semblance hypothesis         Video

10. A framework for consciousness          Video

11. A potential mechanism of anaesthetic agents         Video

Books

Vadakkan K.I (2010) Semblance hypothesis of memory. 3rd Edition ISBN: 978-1-4502-5620-9

Vadakkan K.I (2008) Semblance hypothesis of memory. 2nd Edition ISBN: 978-1-4401-0754-2

Vadakkan K.I (2007) Semblance of activity at the shared post-synapses and extracellular matrices - A structure function hypothesis of memory. ISBN:978-0-5954-7002-0 Download

Presentations

Center for Neuroscience, Indian Institute of Science, Bangalore. August 11th, 2017. Title: Why did Camillo Golgi disagree with the Neuron doctrine?

Society for Neuroscience annual meeting - Satellite event. October 17th, 2015. Title: Examining nervous system functions from a first-person frame of reference using the semblance hypothesis.

Society for Neuroscience annual meeting - Satellite event. November 17th, 2014. Title: Exploring the mind using the semblance hypothesis.

Society for Neuroscience annual meeting - Satellite event. November 2013. Title: Internal Sensations, Artificial intelligence and the semblance hypothesis.

Florida State University, Department of Scientific Computing seminar. February, 2013. Title: Transferable units from natural Intelligence: Proof requires AI development.

University of New Mexico, Department of Computer Science colloquium. January 2013. Title: Natural intelligence to artificial intelligence - A new route that can be taken. (Video) I apologize to the molecular biologists for my comment that discoveries are over in molecular biology. It is the lack of matching advancement in neuroscience that made me to say that).

Society for Neuroscience annual meeting - Satellite event. October 15th, 2012. Title: Reducing internal sensation of retrieved memories using the semblance hypothesis.

Society for Neuroscience annual meeting - Satellite event. November 13th, 2011. Topic: Semblance hypothesis of memory: Computational modelling and development of artificial circuits.

Society for Neuroscience annual meeting - Satellite event. November 14th, 2010. Topic: Semblance hypothesis of memory - Transfer of memories from the hippocampus to the cortex.

Society for Neuroscience annual meeting - Satellite event. October 18th, 2009. Topic: Semblance hypothesis of memory - A presentation.

Abstracts

Vadakkan K.I (2013) A structural unit of brain network that can operate in unison with synaptic connections and can impart needed functions. Cell symposium on the topic "Networked Brain" at the Society for Neuroscience meeting November 8 Poster

Vadakkan K.I (2012) Induced p-semblances as a possible mechanism for the internal sensation of pain. Society for Neuroscience Annual meeting, Oct.16. Abstract 674.25/HH10

Vadakkan K.I (2012) Perception as the integral of semblances formed by re-activation of existing previously formed functional LINKs between the postsynapses. Cognitive Neuroscience Society meeting, April 3rd, Abstract H90

Vadakkan K.I (2011) Semblions induced through inter-postsynaptic functional LINKs, biological parallels of K-lines, as basic units of internal sensations. Society for Neuroscience conference, Abstract 722.16/XX68

Vadakkan K.I (2010) Framework of consciousness from the semblance hypothesis of memory. Toward a science of consciousness Conference, Tucson, University of Arizona. Abstract No: P-8

Vadakkan K.I (2009) Delusions, cognitive impairment and the therapeutic effect of dopamine receptor antagonists in schizophrenia - An explanation through the semblance hypothesis of memory. Society for Neuroscience conference, Poster Abstract: 644.3/U18

Vadakkan K.I (2008) Oxidation-state dependent interconnections between dendritic spines provide early evidence in support of semblance hypothesis of memory. Society for Neuroscience conference, Abstract: 239.19/E16

Vadakkan K.I (2008) Examination of the premises of semblance hypothesis that can explain retrieval-efficient mechanism of memory at appropriate time-scales. Second Canadian Association for Neuroscience annual meeting, Montreal. Abstract A-G 118