Semblance Hypothesis

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Kunjumon Vadakkan

I am Kunjumon Vadakkan. I was born in Kerala, a southern state in India. I started my career as a family physician after my studies (M.B.B.S) at Thrissur Medical college under Calicut University. I studied basic electronics from the Television Training Institute, Francis Road Jn. Calicut. I then started post-graduate studies (M.D) in Biochemistry at the Calicut Medical College. Later, I joined the School of Biotechnology at the Jawaharlal Nehru University as a Research Associate of the Council for Scientific and Industrial Research in the laboratory of Dr. Uttam Pati to study negative regulatory areas upstream of the p53 gene. Then, I worked first at GB Pant hospital and then at Moulana azad Medical College as a Senior Demonstrator in the Department of Biochemistry.

In 1999, I moved to Canada and started working as a Research Assistant in Dr. Casey van Breemen's laboratory in the Department of Pathology and Laboratory Medicine at the University of British Columbia. I completed M.Sc (under Dr. Umberto De Boni) and Ph.D (under Dr. Min Zhuo) in Neuroscience from the Department of Physiology and Program in Neuroscience at the University of Toronto. Then, I did postdoctoral training with Dr. Mark Zylka at the University of North Carolina, Chapel Hill. Following this, I took courses equivalent to two years of B.Sc Physics (including 3rd year modern physics) at the Memorial University, Newfoundland, Canada. I, then completed residency program in Neurology from the Division of Neurology at the University of Manitoba and a fellowship program in Cognitive Neurology under Dr. Sandra Black and Dr. Mario Masellis at the University of Toronto.

Devastating nature of many neurological and psychiatric disorders remains a challenge. So many people are suffering. Fixing certain defects in a system requires understanding of the normal functioning of the system. This will become possible only by examining all the features that the system exhibits at various levels to find the governing principle that can interconnect all of them. In this context, a problem-set was formulated by keeping the first-person internal sensation of higher brain functions at the center, with the hope that it will allow searching for the basic units of operation by continuously asking the questions "What are the real conditions that the solution must satisfy?" (this is required for solving the system), “What else must be present for this to be possible?” (to understand the inter-connectible findings) and “Is there a mechanism that can be replicated in an engineered system?" (required for the gold standard testing of a system that exhibits first-person properties). This approach has provided information regarding the possible structure-function units and their inter-connectable nature that I have explained in my papers.

Attempts to falsify a hypothesis are part of the scientific method. They are highly welcome. I will post all such communication in this website if you don't object. Please contact me by email: kunjumon dot vadakkan at utoronto dot ca

Hosting this website has not been a comfortable experience for me. But I pursued it because the problem at hand is a huge one and it was reasonable to think that deriving a mechanism for the nervous system functions and describing its suitability to explain large number of findings from different levels require a large space. Using this website, I was able to communicate several facts to the community and share several findings as immediately as possible with everyone. This site also provided much-needed inspiration to continue this work. Thank you for visiting. If you have any questions, please email me.

Only through open discussions and debates that we can take science forward. If your institution would like to have a presentation of semblance hypothesis or a debate session, I will be very happy to participate. Please contact me.